Discerning the timing and pattern of late Quaternary glacier variability in the tropical Andes is important for our understanding of global climate change. Terrestrial cosmogenic nuclide (TCN) ages (48) on moraines and radiocarbon-dated clastic sediment records from a moraine-dammed lake at Nevado Huaguruncho, Peru, document the waxing and waning of alpine glaciers in the Eastern Cordillera during the past ∼15 k.y. The integrated moraine and lake records indicate that ice advanced at 14.1 ± 0.4 ka, during the first half of the Antarctic Cold Reversal, and began retreating by 13.7 ± 0.4 ka. Ice retreated and paraglacial sedimentation declined until ca. 12 ka, when proxy indicators of glacigenic sediment increased sharply, heralding an ice advance that culminated in multiple moraine positions from 11.6 ± 0.2 ka to 10.3 ± 0.2 ka. Proxy indicators of glacigenic sediment input suggest oscillating ice extents from ca. 10 to 4 ka, and somewhat more extensive ice cover from 4 to 2 ka, followed by ice retreat. The lack of TCN ages from these intervals suggests that glaciers were less extensive than during the late Holocene. A final Holocene advance occurred during the Little Ice Age (LIA, ca. 0.4 to 0.2 ka) under colder and wetter conditions as documented in regional proxy archives. The pattern of glacier variability at Huaguruncho during the Late Glacial and Holocene is similar to the pattern of tropical Atlantic sea-surface temperatures, and provides evidence that prior to the LIA, ice extent in the eastern tropical Andes was decoupled from temperatures in the high-latitude North Atlantic.