Pyroxenites embedded in peridotite are often invoked as a major cause of short-length scale isotopic heterogeneities in the upper mantle, but there has been little direct evidence. We report spatially controlled chemical and Sr-Nd isotopic compositions of pyroxenites and their host peridotites from an ophiolitic mantle sequence in the Northern Apennines, Italy, with depleted mantle compositions, representing a surface exposure of veined upper mantle, a potential source for mid-oceanic-ridge basalts (MORB). Interaction between pyroxenites and adjacent mantle rocks results in centimeter-scale chemical modifications in the host peridotites, systematically lowering their Sm/Nd ratios. Over time, this interaction causes the host peridotite at >0.1 m scale to acquire an isotopic heterogeneity larger than the range defined by the peridotite and pyroxenite end-members. Moreover, the 143Nd/144Nd variation of a single outcrop covers most of the global Nd isotopic variability documented in abyssal peridotites. Such pyroxenite-peridotite veined mantle domains may represent the enriched component rarely found in abyssal peridotites, but often invoked to account for the low end of 143Nd/144Nd variations in MORB.