The recent discovery of episodic tremor and slip (ETS) in subduction zones is based on slow slip episodes visible in global positioning system observations correlated with nonvolcanic tremor signals on seismometers. ETS occurs just inboard from a region capable of great megathrust earthquakes; however, whether there is any communication between these two processes remains unknown. In this study we use new single-station methods to compile an ETS catalog for the entire Cascadia subduction zone, offshore western North America, and compare the patterns with a variety of along-strike trends for the subducting and overriding plates. Correlated ground vibrations and strain observations are found all along the subduction zone, demonstrating that ETS is an inherent part of the subduction process. There are three broad (300–500 km), coherent zones with different recurrence intervals (14 ± 2, 19 ± 4, 10 ± 2 months), where the interval duration is inversely proportional to upper plate topography and the spatial extent correlates with geologic terranes. These zones are further divided into segments of ETS that occur at times typically offset from each other. The seven largest (100–200 km) segments appear to be located immediately landward from forearc basins interpreted as manifestations of megathrust asperities, implying that there is a spatial link between ETS and earthquake behavior. It is not yet clear if any temporal link exists, but the regional time between ETS episodes could be controlled by strength variations due to composition of geologic terranes.