Two episodes of meltwater influx from glacial Lake Agassiz are recorded as prominent sedimentologic, isotopic, magnetic, and faunal signatures in southern Lake Michigan profundal sediments. As a tributary to the main path of eastward Lake Agassiz flow, southern Lake Michigan recorded only the largest, catastrophic discharges. The distinctive Wilmette Bed, a massive gray mud that interrupts laminated red glaciolacustrine clays, marks the first episode, which occurred near the beginning of the Younger Dryas cooling event. The associated discharge may have played a role in the inception or severity of the Younger Dryas event. An oxygen isotope excursion in biogenic carbonate and changes in ostracode assemblages mark the second episode, which appears to have had at least two pulses, dated by accelerator mass spectrometer 14C ages on biogenic carbonate at about 8.9 and 8.6 ka. The second episode occurred during the early Holocene peak in global meltwater discharge and apparently had little wide- spread climatic or oceanographic effect. The contrast between the effects associated with these two episodes of meltwater discharge emphasizes the complexity of the ice sheet-ocean-climate system.