The venting at the northern Peru convergent margin, unlike at other margins, has produced large barite deposits, which have not been observed outside the vents. The 87Sr/86Sr isotopic ratios of the fluids are more radiogenic than seawater. To explain these elevated values, we propose either the influence of a fluid characterized by a more radiogenic signature originating from the continent, or a reaction between seawater and the underlying continental metamorphic basement. The presence of this nonlocal radiogenic component is marked more strongly on the 87Sr/86Sr ratios measured in the barite deposits. We assume that the fluid sampled at the venting site and the fluid responsible for the barite deposit sampled at the same site originated from the same source, i.e., the Paleozoic metamorphic basement of the Andean continental margin.