The Mississippian Antler foreland basin contains siliciclastic sedimentary rocks that record a series of orogenic events along the western margin of North America from about 350 to 320 Ma. Our new stratigraphic and sedimentologic studies in Nevada indicate that the strata are not generally progradational as previously described, and that uplift played a large role in basin evolution. We have recognized three unconformity-bounded stratigraphic sequences in the Antler basin in central Nevada: the Diamond Range submarine-fan system, the Newark Valley fluvial and delta-plain system, and the Green Springs deltaic and shelf-carbonate system. We propose a two-phase history for the Antler orogeny: (1) collision of the western edge of North America with the Antler allochthon and downwarping of the continental margin (360-350 Ma), which resulted in deposition of the Diamond Range submarine-fan system; and (2) uplift and low-amplitude folding of the basin (350-320 Ma), accompanied by deposition of a thin veneer of reworked siliciclastic sediments (Newark Valley and Green Springs sequences) across a shallow-marine shelf. Siliciclastic sedimentation wanned in the Late Misissippian and Early Pennsylvanian, and gradually gave way to carbonate sedimentation.