Results of two-dimensional flexural modeling of the northern Bighorn and northern Green River basins in the Wyoming foreland province suggest that these basins formed as flexures in response to loading by basin-margin uplifts and basin sedimentary sequences. The northern Bighorn Basin subsided due to loading by the Beartooth uplift along its western margin. The northern Green River Basin developed as a result of concurrent loading by the Wyoming thrust belt to the west and the Wind River uplift to the east. Tectonic loading from basement-involved uplifts played a major role in subsidence and sedimentation, as evidenced by isopach patterns within each basin. Lithospheric flexural rigidities of 1021 to 1022 newton metres (N·m) can adequately explain subsidence in both basins.