The Middle to Late Jurassic age Coast Range ophiolite (CRO) of California contains two geochemically distinct volcanic rock associations that formed in different tectonic settings. Volcanic rocks from the southern CRO (Point Sal, Cuesta Ridge, Stanley Mountain, Llanada, Quinto Creek, and Del Puerto) and parts of the northern CRO (Healdsburg, Elder Creek) are similar to low-K tholeiites and calc-alkaline rocks of the island-arc suite. The thin volcanic sections of these ophiolite remnants suggest formation by intra-arc rifting. In contrast, volcanic rocks from Stonyford seamount and Paskenta in the northern CRO are transitional subalkaline metabasalts with geochemical characteristics similar to enriched mid-ocean ridge basalts or ocean-island tholeiites. These rocks are associated with Tithonian radiolarian cherts and may be part of the Franciscan Complex. Alternatively, they may represent a change in tectonic setting within the CRO during the Late Jurassic. Regardless, the CRO as currently conceived cannot be considered a single terrane with one mode of origin.