Newly generated and previously published strontium isotope signatures of plagioclase phenocrysts in Columbia River Basalt Group lavas exhibit heterogeneity largely imposed by mantle-derived magmas assimilating variable crustal rocks. Steens basalts assimilated accreted terrane crust with ⁸⁷Sr/⁸⁶Sr ratios of <0.7040. In contrast, Imnaha, Grande Ronde, Wanapum, and Saddle Mountains basalts likely assimilated crust with more radiogenic Sr (>0.7040) including a cratonic component, perhaps as a result of residence in magma chambers partly located east of the ⁸⁷Sr/⁸⁶Sr = 0.7060 line. Strontium isotope ratios in plagioclase phenocrysts from early- erupted Imnaha basalts anticipate whole-rock signatures of later-erupted Grande Ronde basalts consistent with a geochemical continuum between the two formations, which is also seen in whole-rock trace element abundances, undermining the notion of an abrupt change in the magma sources generating Imnaha and Grande Ronde basalts.