Depth-dependent variations in the structure and composition of continental crust can be studied via integrated investigations of isobaric terranes. In this contribution, we summarize three isobaric terranes in Archean to Proterozoic crust. In western Canada, 35–45-km-deep lower crust is exposed over an area of more than 20,000 km². The Upper Granite Gorge of Grand Canyon, Arizona, provides a transect of 20–25-km-deep middle crust. The Proterozoic basement of central Arizona represents an isobaric exposure of 10–15-km-deep middle crust. Isobaric terranes yield a conceptual image of continental crust that can be compared to seismic images, xenolith data, and drill core data to clarify rheology, coupling/decoupling of crustal levels, and the interplay between deformation, metamorphism, and plutonism. General observations include: (1) The crust is heterogeneous at all levels and cannot be accurately modeled as a simple progression from quartz-rich to feldspar-rich lithologies or from felsic to mafic bulk compositions. (2) The crust is segmented into foliation domains that alternate between steeply dipping and shallowly dipping. (3) Magmatism is expressed differently at different depths due to different background temperatures and a general upward distillation from mafic to felsic composition, and may be the most important control on crustal architecture and rheology. The strength of continental crust (and its potential for low-viscosity flow) is not simply a function of temperature, depth, and compositional layering, but is controlled by the size and distribution of rheological domains. The rheological character of a particular layer can vary in space and time at any crustal level.