The eastern Transverse Ranges provide essentially continuous exposure for >100 km across the strike of the Mesozoic Cordilleran orogen. Thermobarometric calculations based on hornblende and plagioclase compositions in Mesozoic plutonic rocks show that the first-order distribution of rock units resulted from differential Laramide exhumation. Mesozoic supracrustal rocks are preserved in the relatively little exhumed eastern part of the eastern Transverse Ranges and south-central Mojave Desert, and progressively greater rock uplift and exhumation toward the west exposed rocks originating at mid-crustal depths. The eastern Transverse Ranges thus constitute a tilted, nearly continuously exposed crustal section of the Mesozoic magmatic arc and framework rocks from subvolcanic levels to paleodepths as great as ~22 km. The base of this tilted arc section is a moderately east-dipping sheeted magmatic complex >10 km in width by 70 km in length, constructed structurally beneath, yet synchronous with Late Jurassic and Cretaceous upper-crustal plutons. Geochronology and regional structural relations thus suggest that arc magmas generated in the lower crust of this continental arc interacted in a complex mid-crustal zone of crystallization and mixing; products of this zone were parental magmas that formed relatively homogeneous upper crustal felsic plutons and fed lavas and voluminous ignimbrites.