Recent chronologic and stratigraphic studies in the northwestern Himalayan foreland basin have led to better constrained deformational and depositional histories. In order to test the hypothesis that considerable pre-Pleistocene uplift occurred in the Salt Range of northern Pakistan, the stratigraphic record adjacent to the central and eastern Salt Range has been examined. Unconformities, paleomagnetically documented tectonic rotations across these unconformities, and changes in the paleocurrent directions, provenance, and rates of sediment accumulation serve to delineate an interval of early Pliocene uplift of the Salt Range, as well as several late Pliocene–Pleistocene uplift events in this range and adjacent structures. Stratigraphic, reflection seismic, and structural data indicate that these uplift events resulted from thrusting related to the salt-lubricated Potwar detachment. When considered in conjunction with the chronology of deformation in other parts of the foreland, these data clearly indicate that out-of-sequence thrusting has occurred on a large scale (>100 km) during the past 6 m.y. This pattern of deformation supports the concept that an irregular spatial and temporal distribution of shortening should be expected to occur within an advancing thrust wedge.