Although he was legally blind, Charles R. Knight (1874–1953) established himself as the premier paleontological artist in the early 1900s. When the Field Museum, Chicago, commissioned a series of large paintings to document the evolution of life, Knight was the obvious choice. Knight considered himself an artist guided by science; he researched and illustrated living animals and modern landscapes to better understand and represent extinct life forms within their paleoecosystems. Knight began the process by examining fossil skeletons; he then constructed small models to recreate the animals’ life anatomy and investigate lighting. Once details were finalized, Knight supervised assistants to transfer the study painting to the final mural. The Field Museum mural process, a monumental task of translating science into public art, was accompanied by a synergistic tension between Knight, who wanted full control over his artwork, and the museum’s scientific staff; the correct position of an Eocene whale’s tail—whether uplifted or not—documents a critical example. Although modern scientific understanding has rendered some of Knight’s representations obsolete, the majority of his 28 murals remain on display in the Field Museum’s Evolving Planet exhibit. Museum educators contrast these murals with contemporary paleontological knowledge, thereby demonstrating scientific progress for better public understanding of the nature of science.