Fluid release structures resulting from the interaction of igneous intrusions with sedimentary basins form an important part of the evolution of large igneous provinces. Hydrothermal breccia pipes formed in the Karoo Basin in South Africa during emplacement of igneous sills in the Karoo large igneous province represent one of the best-exposed expressions of such venting structures. Earlier work has shown that degassing of thermogenic CO₂ and CH₄ through the breccia pipes may have contributed to the Early Jurassic environmental changes. Here, we present the first detailed analysis of the distribution of breccia pipes in the western parts of the Karoo Basin. We mapped 431 pipes in a 650 km² area using outcrop data. The pipes are rooted in contact aureoles around four sills emplaced in organic-rich Ecca Group shale, and thermal modeling of sill cooling and contact metamorphism gives a maximum temperature of 675 °C near the sill contacts, sufficient to convert a significant fraction of the organic carbon to gas. Model estimates indicate that metamorphism in the 650 km² area generated 75–88 Gt of CO₂, depending on actual sill thicknesses and emplacement levels. When further up-scaled, an area of 7400–8700 km² (i.e., less than 2% of the area in the Karoo Basin intruded by sills) would be required to generate 1000 Gt of CO₂. In order to characterize the degassing pipes, their geographical positions and diameters were analyzed using several point-pattern methods. The results showed that the pipes (1) have diameters in the 11–177 m range (average 44 m), (2) are spaced with an average nearest-neighbor distance of 452 m, and (3) are overall randomly spaced but with weak overdispersion at very small scales (<50 m) and weak clusters at larger scales (400–3000 m). In contrast to studies of volcanic pipe spacing, this study on breccia pipes does not indicate that the pipe spacing is controlled by any large-scale geophysical parameters such as crustal or basin thicknesses. Conclusions point to the pipes being formed following sill emplacement and pressure increase in the low-permeability organic-rich shale, followed by rapid carbon degassing, emphasizing their important role in the Early Jurassic climate change and oceanic anoxic event.