This volume, prepared for the 130th Annual Meeting of the Geological Society of America in Indianapolis, includes compelling science and field trips in Indiana, Illinois, Kentucky, Michigan, and Ohio. A wealth of geologic and human history collides in the Midwest, a confluence that led to the growth of America's industry over the past two centuries. Guides in this volume depict this development from the establishment of New Harmony, the birthplace of American geology, through the construction of Indianapolis's modern skyline. Underpinning this growth were the widespread natural resources-limestone, coal, and water-that built, powered, and connected a growing nation. Take a journey through the Heartland to sand dunes, outcrops, quarries, rivers, caves, and springs that connect Paleozoic stratigraphy with the assembly of Gondwana, continental glaciation with Quaternary geomorphology and hydrology, and landscape with the human environment.