Low-temperature thermochronological ages of samples from the central Andes correlate with major tectonic events during Late Cretaceous and Cenozoic times. Apatite fission-track (AFT) ages show prominent clusters during the Early–Late Cretaceous in the Coastal Cordillera and the Cordillera de Domeyko; Paleocene–Oligocene ages in the western Puna Plateau and Cordillera de Domeyko; and latest Eocene–Pliocene ages in the Eastern Cordillera. These ages track the expansion of the Andean orogenic edifice, the eastern front of which migrated rapidly eastward ~200 km and ~150 km during late Eocene and Pliocene times, respectively. During the intervening time interval, ca. 35–5 Ma, the orogenic strain...