Abstract A dataset with pore pressures from more than 1000 exploration wells has been used to investigate the dynamics of aquifer systems in the Norwegian Continental Shelf (NCS). Variations in aquifer pressures reflect flow of porewater through permeable rocks over geological time. Strongly overpressured regimes are formed within confined aquifers in subsiding areas, where fluid flow out of the aquifer is controlled by vertical seepage. In transitional pressure regimes, fluid flows within permeable beds towards areas with hydrostatic pressures. In the hydrostatic regime, pressure differences result from density differences due to varying formation water salinity and by hydrocarbon columns. An underpressured regime has been encountered in confined aquifers in the platform areas of the Barents Sea, and is related to net uplift and erosion. In the case studies, pressure differences are interpreted in the context of the relevant pressure regime, and with a dynamic approach where segment boundaries and cap rocks are regarded as low-permeability restrictions rather than barriers. The present distribution of pressure regimes was developed over the last few million years due to rapid Pleistocene sedimentation and erosion processes.