Abstract We construct a Paleogene North America-Gulf of Mexico sediment budget, accounting for sources and sinks, to constrain the temporal and spatial distribution of sediment. Sediment supply is derived from empirical geomorphic relationships, as well as an integrated, source-to-sink numerical model of landscape evolution for denudation linked to fluvial and deltaic sediment transport and deposition. Knowledge of sediment supply from source areas informs predictions of unaccounted deposits of the deep-water Wilcox Formation by assuming budget closure. These first-order predictions can be coupled with high-resolution, probabilistic geomorphic and stratigraphic scaling relationships to provide long-range trends in depositional facies and architecture that link to oil and gas reservoir modeling.