ABSTRACT The Bighorn uplift, Wyoming, developed in the Rocky Mountain foreland during the 75–55 Ma Laramide orogeny. It is one of many crystalline-cored uplifts that resulted from low-amplitude, large-wavelength folding of Phanerozoic strata and the basement nonconformity (Great Unconformity) across Wyoming and eastward into the High Plains region, where arch-like structures exist in the subsurface. Results of broadband and passive-active seismic studies by the Bighorn EarthScope project illuminated the deeper crustal structure. The seismic data show that there is substantial Moho relief beneath the surface exposure of the basement arch, with a greater Moho depth west of the Bighorn uplift and shallower Moho depth east of the uplift. A comparable amount of Moho relief is observed for the Wind River uplift, west of the Bighorn range, from a Consortium for Continental Reflection Profiling (COCORP) profile and teleseismic receiver function analysis of EarthScope Transportable Array seismic data. The amplitude and spacing of crystalline-cored uplifts, together with geological and geophysical data, are here examined within the framework of a lithospheric folding model. Lithospheric folding is the concept of low-amplitude, large-wavelength (150–600 km) folds affecting the entire lithosphere; these folds develop in response to an end load that induces a buckling instability. The buckling instability focuses initial fold development, with faults developing subsequently as shortening progresses. Scaled physical models and numerical models that undergo layer-parallel shortening induced by end loads determine that the wavelength of major uplifts in the upper crust occurs at approximately one third the wavelength of folds in the upper mantle for strong lithospheres. This distinction arises because surface uplifts occur where there is distinct curvature upon the Moho, and the vergence of surface uplifts can be synthetic or antithetic to the Moho curvature. In the case of the Bighorn uplift, the surface uplift is antithetic to the Moho curvature, which is likely a consequence of structural inheritance and the influence of a preexisting Proterozoic suture upon the surface uplift. The lithospheric folding model accommodates most of the geological observations and geophysical data for the Bighorn uplift. An alternative model, involving a crustal detachment at the orogen scale, is inconsistent with the absence of subhorizontal seismic reflectors that would arise from a throughgoing, low-angle detachment fault and other regional constraints. We conclude that the Bighorn uplift—and possibly other Laramide arch-like structures—is best understood as a product of lithospheric folding associated with a horizontal end load imposed upon the continental margin to the west.