... of the important “ore-forming elements” are fixed into metalloproteins such as cobalamine (Co), cytochrome oxidase (Fe, Cu), alcohol dehydrogenase (Zn), and xanthine oxidase (Mo, Fe). Most proteins including metalloproteins degrade between 60° and 70°C. Until that critical temperature is reached, such metals...

...Francis Albarède Abstract Metalloproteins play essential roles in biology and medicine. Calcium is a major component of bones, while electron and oxygen transport in the body relies on iron and copper. Isotope fractionation of metal stable elements uniquely reflects specific biochemical pathways...

...F igure 3 Extant metabolic pathways of glycolysis and the citric acid cycle highlighting the steps catalyzed by metalloproteins. Only the metal cofactor for each metalloenzyme is noted. The reactions shaded pink are for the glycolysis pathway; those shaded green are for the citric acid cycle...

...Figure 2 Example of complex coordination encountered in two metalloproteins. The ferroxidase enzyme ceruloplasmin (Cp, PDB ID: 1KCW ( Zaitseva et al. 1996 )) is the major copper-carrying protein in the blood, and oxidizes seric iron. The large Cu ion in the center is labeled A 1055, while...

.... , 2013 , Zinc-binding proteins, abundance , in Kretsinger , R.H. , Uversky , V.N. , and Permyakov , E.A. , eds., Encyclopedia of Metalloproteins : New York , Springer , p.  2549 – 2554 , https://doi.org/10.1007/978-1-4614-1533-6_180 . Bradley , D.C. , 2011 , Secular...

... is characterized by relatively abundant transition metals, including Mn, Ni, and Cu, which form key components of metalloproteins with various duties. The complex communication system in the brain requires abundant Na and K together with Ca for the nerves and membranes. Thus, assuming some overall...

.... , 2001 ). Benzimidazole (BIH) is of interest for a variety of reasons. It acts as a ligand in a variety of biological molecules ( Kaim & Schwederski, 1991 ) and is used in model compounds for metalloproteins ( Plesch et al. , 1997 ). It is well known that the coordination ability...

... to study the same kind of molecular interactions discussed hereafter, but without spatial resolution. Examples include organic-mineral interaction at the binding sites in metalloproteins ( Benfatto et al. 2003 ) or between metal ion and humic macromolecules ( Myneni et al. 1999 ; 2002a...

... enzymes and metalloproteins on the one hand and the solution used as a feeding medium by cells on the other hand. More significant 65 Cu/ 63 Cu fractionation of −0.5 to −1.5‰ with the source material were observed in controlled cultures for azurin, metallothionein, and superoxide dismutase (Zhu et al...

.... Colaresi J. Yocum M. Mullins O.C. Chen C.T. ( 1992 ) Soft-ray spectroscopy of metalloproteins using fluorescence detection . Nuclear Instruments and Methods in Physics Research Section A , 319 , 285 – 289 . Cressey G. Henderson C.M.B. van der Laan G. ( 1993 ) Use...

.... Recent studies also indicate that organochlorines are present at high concentrations in the organic fraction of soils and natural waters, and warrant the consideration of these molecules and other organohalogens in all biogeochemical reactions. Although metalloproteins and enzymes derived from parent...

... transported to nerve terminals ( Borchelt et al. 1994 ), suggesting that PrP C is important for neuronal activity. PrP C also appears to be a metalloprotein binding copper in vivo ( Brown et al. 1997 ), and perhaps an endocytic receptor for the uptake of extracellular copper ( Pauly and Harris 1998...

... , https://doi.org/10.2138/am-2018-6259 . McGuinness , K.N. , Klau , G.W. , Morrison , S.M. , Moore , E.K. , Seipp , J. , Falkowski , P.G. , and Nanda , V. ( 2022 ) Evaluating mineral lattices as evolutionary proxies for metalloprotein evolution . Origins of Life...

.... Luchinat C. Parigi G. Pieratelli R. ( 2005 ) NMR spectroscopy of paramagnetic metalloproteins . ChemBioChem , 6 , 1536 – 1549 . Boffa Ballaran T. Carpenter M.A. Geiger C.A. Koziol A. ( 1999 ) Local structural heterogeneity in garnet solid solutions . Physics...

... , M.C. , Latimer , M.J. , Poulos , T.L. , Sevrioukova , I.F. , Hodgson , K.O. , and Hedman , B. ( 2007 ) Photoreduction of the active site of the metalloprotein putidaredoxin by synchrotron radiation . Acta Crystallographica , D63 ( 9 ), 951 – 960 . Cottrell , E...