Abstract The Nansatsu district of southern Kyushu has been the site of calc-alkaline volcanism for the last 10 m.y., shifting eastward with time. Associated hydrothermal activity followed deposition of the volcanic host rocks by about 0.5 m.y. and was characterized by interaction of magmatic fluids with meteoric water under epithermal conditions, resulting in the formation of high sulfidation Cu-Au deposits at Kasuga, Iwato, and Akeshi. The orebodies consist of >95 wt percent SiO 2 and result from leaching of the original andesite lava and pyroclastic flows by acid chloride-sulfate waters. These are inferred to have formed when magmatic vapors containing HCl and SO 2 condensed into meteoric water. The residual silica (now quartz) orebodies are best developed where the host was initially permeable. The margins of the quartz bodies are abrupt, with narrow (1-2 m) halos representing the reaction front of acid waters isochemically dissolving the host rock. The halo comprises alunite (strongly zoned in Na and K, with P-rich cores), dickite, and/or kaolinite ± pyrophyllite, grading out into illite and interlayered illite-smectite clays, and finally, propylitic alteration. This pattern is characteristic of deposits of this type throughout the world, for example, at Summitville, Colorado, and Lepanto, Philippines. Mineralization occurred after initial leaching by the vapor condensates, with metals transported by a dense magmatic fluid. Mixing with meteoric water and the subsequent temperature decrease caused the general decrease in grade toward the margin of the quartz bodies; ore grades are restricted to the quartz bodies. Gold is most closely associated with enargite and pyrite; later minerals include covellite and then sulfur. The last stage of activity was steam-heated, with descending waters oxidizing sulfides to goethite and locally remobilizing Au into fractures (this varies in degree between deposits). Erosion exposed the orebodies to supergene weathering, continuing the sulfide oxidation and Au remobilization. Stable isotope results indicate that hypogene alunite formed from a mixture of magmatic fluid (δ 18 O = 7 ± 2‰, δD = −25 ± 5‰, similar to nearby active volcanic discharges) with local meteoric water. In contrast, the clays in the marginal halo have isotopic compositions indicating a δ 18 O shift of 6 to 8 per mil from local meteoric water values, probably due to water-rock interaction, and the δ 18 O values of residual silica quartz may also be due to meteoric water domination. Fluid inclusion study of postmineralization quartz crystals indicates that the fluids had a salinity of about 1 wt percent NaCl equiv during late quartz growth, though there is evidence in one sample for higher salinity fluid having been present, up to 30 wt percent NaCI equiv (some inclusions contain daughter minerals of halite and sulfur). The T h values of over 1,000 measurements on late quartz from the ore zones indicate that the mean temperature during that stage ranged from <200°C at Akeshi to about 200°C at Iwato and 230°C at Kasuga. The presence of vapor-rich inclusions, some with T hv similar to T hl , indicate the presence at times of a two-phase fluid in the center of the ore zones, with depths of about 150 to 300 m below the paleowater table. The mineralizing fluid was relatively oxidized (sulfide/ sulfate ratio about 3:1), close to pyrite-alunite coexistence. Under these redox conditions, a pH of 3 and over a temperature range of 200° to 300°C, AuCl 2 − complexing may dominate over HAu(SH) 2 at salinities above about 2 wt percent NaCl. Several conditions are conducive for high sulfidation mineralization to occur: a crystallizing magma exsolves a fluid, with lower pressure conditions favoring metal fractionation from melt to fluid, the exsolved fluid separates into vapor and saline liquid phases due to immiscibility, with the latter being metal rich, the gas-rich (HCl and SO 2 + H 2 S) vapor ascends to the surface, with at least a portion condensed into meteoric water, forming an acid fluid which leaches the host rock to create permeable zones for later mixing, and the dense, metal-bearing fluid also ascends into this leached zone and precipitates Cu sulfosalts, sulfides, and Au upon mixing with meteoric water . If the saline liquid is not released from its source adjacent to the magma, due to lack of fracturing, or if there is a strong hydraulic gradient caused by high relief, only the vapor-related stage may occur. This will leave leached, barren rock which is characteristic of many eroded volcanic terranes.