Abstract The New Siberian Islands are affected by a number of Mesozoic tectonic events. The oldest event (D1a) is characterized by NW-directed thrusting within the South Anyui Suture Zone combined with north–south-trending sinistral strike-slip in the foreland during the Early Cretaceous. This compressional deformation was followed by dextral transpression along north–south-trending faults, which resulted in NE–SW shortening in the Kotelny Fold Zone (D1b). The dextral deformation can be related to a north–south-trending boundary fault zone west of the New Siberian Islands, which probably represented the Laptev Sea segment of the Amerasia Basin Transform Fault in pre-Aptian–Albian times. The presence of a transform fault west of the islands may be an explanation for the long and narrow sliver of continental lithosphere of the Lomonosov Ridge and the sudden termination of the South Anyui Suture Zone against the present Laptev Sea Rift System. The intrusion of magmatic rocks 114 myr ago was followed by NW–SE-trending sinistral strike-slip faults of unknown origin (D2). In the Late Cretaceous–Paleocene, east–west extension (D3) west of the New Siberian Islands initiated the development of the Laptev Sea Rift System, which continues until today and is largely related to the development of the Eurasian Basin.