ABSTRACT We analyzed 37 large oceanic intraplate earthquakes (M >6). The largest (M >7) are mainly concentrated under the Indian Ocean. Moderate events (6 < M < 7) are sparsely distributed under the Indian Ocean and other oceans where lithospheric ages are between 90 Ma and 20 Ma. Oceanic intraplate events related to mantle plumes or hotspots are rare, though low-velocity anomalies beneath hotspots are a common feature. Tomographic cross sections for Indian Ocean areas with large intraplate earthquakes indicate strong heterogeneity in the mantle. These earthquakes are explained by shallow stress variations caused by a combination of tectonic forces including slab-pull, ridge-push, drag by mantle flow, plume-push, and buoyancy forces as a consequence of low-velocity anomalies in the mantle. Oceanic intraplate seismicity in the Indian Ocean is related to the large-scale, low-velocity anomaly structure around the Ninety East Ridge.