Abstract The development of overpressure in continental margins is typically evaluated with hydrogeological models. Such approaches are used to both identify fluid flow patterns and to evaluate the development of high pore pressures within layers with particular physical properties that may promote slope instability. In some instances, these models are defined with sediment properties based on facies characterization and proxy values of porosity; permeability or compressibility are derived from the existing literature as direct measurements are rarely available. This study uses finite-element models to quantify the differences in computed overpressure generated by fine-grained hemipelagic sediments from the Gulf of Cadiz, offshore Martinique and the Gulf of Mexico, and their consequences in terms of submarine slope stability. By comparing our simulation results with in situ pore pressure data measured in the Gulf of Mexico, we demonstrate that physical properties measured on volcanic-influenced hemipelagic sediments underestimate the computed stability of a submarine slope. Physical properties measured on sediments from the study area are key to improving the reliability and accuracy of overpressure models, and when that information is unavailable, literature data from samples with similar lithologies, composition and depositional settings enable better assessment of the overpressure role as a pre-conditioning factor in submarine landslide initiation.