This article summarizes the geological setting, spatial-temporal distribution, and major-element, trace-element, and Nd-Sr-Pb isotopic compositional variation of rocks representative of Tibetan postcollisional magmatic activity. The implications of petrogenesis and spatial-temporal distribution are discussed in relation to lithospheric mantle heterogeneity and a possible role for collision-induced asthenospheric mantle flow. Rocks indicative of postcollisional volcanism are widely distributed across the terranes making up the Tibetan plateau. Three stages of activity are recognized (ca. 45–25, 25–5, and 5–0 Ma), mostly conforming to potassic to ultrapotassic shoshonitic and high-potassium calc-alkaline types. These show strong relative enrichments in large-ion lithophile elements (LILE), U, Th, and light rare earth elements (LREE); depletions in high field strength elements (HFSE) and heavy rare earth elements (HREE)—with (La/Yb) N ratios ranging from 4.3 to 699, mainly 40–50; ∑REE and abundances of 50–2560 ppm, mainly 300–500 ppm—in most cases lacking significant negative Eu anomalies. However, the element distributions for kamafugite and carbonatite show ocean island basalt–like nondepleted or even slightly enriched HFSE patterns. The plots of ϵNd versus 87 Sr/ 86 Sr define a mixing array between Neo-Tethyan mid-ocean ridge basalts (MORB) and High Himalayan crustal compositions, with ϵNd(t) varying from +5.95 to −17.42 and 87 Sr/ 86 Sr (i) 0.702059 to 0.746320. The range of Nd and Sr isotopic compositions in the northern parts of the plateau, Sanjiang, and west Qinling is relatively small compared to that from Gangdese to the south, where 87 Sr/ 86 Sr ratios range from 0.703785 to 0.746320 and 143 Nd/ 144 Nd from 0.511737 to 512710. The variation of Pb isotopic ratios is somewhat less, with 206 Pb/ 204 Pb ranging from 18.149 to 19.345, 207 Pb/ 204 Pb from 15.476 to 15.803, and 208 Pb/ 204 Pb from 37.613 to 40.168. In general, magmatic isotopic compositions indicate the regional-scale presence of DUPAL-like mantle, reflecting additions of the “enriched mantle” components (EM1, EM2) to an ambient MORB-HIMU (high μ, i.e., high U/Pb mantle) asthenospheric hybrid. The observed geochemical, isotopic, and mineral phase compositional variations of primitive magmatic products and their entrained mantle xenoliths clearly suggest LILE-enriched and HFSE-depleted phlogopite/amphibole–bearing mantle wedge sources contaminated by (presumably subduction-related) hydrous fluids or smallfraction H 2 O-CO 2 –rich melts. Tibetan lithospheric mantle appears to reflect the presence of and interaction between at least three compositional end-members. The overall spatial-temporal pattern of Tibetan collisional and postcollisional activity is consistent with the hypothesis that the Neo-Tethyan asthenospheric mantle was laterally displaced along discrete northeast- and southwestward flow channels in response to the IndiaAsia collision.