Abstract Erebus volcano, Antarctica, is the southernmost active volcano on the globe. Despite its remoteness and harsh conditions, Erebus volcano provides an unprecedented and unique opportunity to study the petrogenesis and evolution, as well as the passive and explosive degassing, of an alkaline magmatic system with a persistently open and magma-filled conduit. In this chapter, we review nearly five decades of scientific research related to Erebus volcano, including geological, geophysical, geochemical and microbiological observations and interpretations. Mount Erebus is truly one of the world's most significant natural volcano laboratories where the lofty scientific goal of studying a volcanic system from mantle to microbe is being realized.