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Metal stable isotopes in the human body; a tribute of geochemistry to medicine

Francis Albarede
Metal stable isotopes in the human body; a tribute of geochemistry to medicine (in Social and economic impact of geochemistry, John Ludden (editor), Francis Albarede (editor) and Max L. Coleman (editor))
Elements (August 2015) 11 (4): 265-269

Abstract

Metalloproteins play essential roles in biology and medicine. Calcium is a major component of bones, while electron and oxygen transport in the body relies on iron and copper. Isotope fractionation of metal stable elements uniquely reflects specific biochemical pathways. Variations in these isotope ratios from normal levels in body fluids can be used as reliable markers of pathological conditions. Metal stable isotope fractionation reflects the energetics of bonding, is amenable to theoretical calculations and is fast becoming a powerful medical diagnostic tool. Examples include how calcium isotopes can be used to monitor bone loss, how iron isotopes can react to genetic disorders, and how copper isotopes can help track cancer progression.


ISSN: 1811-5209
Serial Title: Elements
Serial Volume: 11
Serial Issue: 4
Title: Metal stable isotopes in the human body; a tribute of geochemistry to medicine
Title: Social and economic impact of geochemistry
Author(s): Albarede, Francis
Author(s): Ludden, Johneditor
Author(s): Albarede, Franciseditor
Author(s): Coleman, Max L.editor
Affiliation: Ecole Normale Superieure de Lyon, Lyon, France
Affiliation: British Geological Survey, United Kingdom
Pages: 265-269
Published: 201508
Text Language: English
Publisher: Mineralogical Society of America and Mineralogical Society of Great Britain and Ireland and Mineralogical Association of Canada and Geochemical Society and Clay Minerals Society, International
References: 30
Accession Number: 2016-002083
Categories: Isotope geochemistry
Document Type: Serial
Bibliographic Level: Analytic
Illustration Description: illus.
Secondary Affiliation: Ecole Normale Superieure de Lyon, FRA, FranceCalifornia Institute of Technology, USA, United States
Country of Publication: International
Secondary Affiliation: GeoRef, Copyright 2017, American Geosciences Institute. Abstract, copyright, Mineralogical Society of America
Update Code: 201601
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