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Preservation of the bone protein osteocalcin in dinosaurs

Gerard Muyzer, Philip A. Sandberg, Marjo H. J. Knapen, Cees Vermeer, Matthew Collins and Peter Westbroek
Preservation of the bone protein osteocalcin in dinosaurs
Geology (Boulder) (October 1992) 20 (10): 871-874


Two different immunological assays were used to identify the remains of a bone matrix protein, osteocalcin (OC), in the bones of dinosaurs and other fossil vertebrates. Antibodies raised against OC from modern vertebrates showed strong immunological cross-reactivity with modern and relatively young fossil samples and significant reactions with some of the dinosaur bone extracts. The presence of OC was confirmed by the detection of a peptide-bound, uniquely vertebrate amino acid, gamma carboxyglutamic acid (Gla). Preservation of OC in fossil bones appears to be strongly dependent on the burial history and not simply on age. These results extend the range of protein preservation in the geologic record and provide a first step toward a molecular phylogeny of the dinosaurs.

ISSN: 0091-7613
EISSN: 1943-2682
Serial Title: Geology (Boulder)
Serial Volume: 20
Serial Issue: 10
Title: Preservation of the bone protein osteocalcin in dinosaurs
Affiliation: Leiden Univ., Geobiochem. Unit, Leiden, Netherlands
Pages: 871-874
Published: 199210
Text Language: English
Publisher: Geological Society of America (GSA), Boulder, CO, United States
References: 34
Accession Number: 1992-041117
Categories: Vertebrate paleontologyGeochemistry of rocks, soils, and sediments
Document Type: Serial
Bibliographic Level: Analytic
Illustration Description: illus. incl. 2 tables
N49°00'00" - N60°00'00", W120°00'00" - W110°00'00"
N42°00'00" - N49°00'00", W117°15'00" - W111°04'60"
S09°00'00" - S05°40'00", E105°04'60" - E114°40'00"
N37°55'00" - N39°43'00", W79°30'00" - W75°04'60"
S47°30'00" - S34°30'00", E166°30'00" - E178°30'00"
N32°04'00" - N35°12'00", W83°15'00" - W78°31'60"
N42°30'00" - N45°55'00", W104°04'60" - W96°27'00"
Secondary Affiliation: Univ. Ill., USA, United StatesUniv. Limburg, NLD, Netherlands
Country of Publication: United States
Secondary Affiliation: GeoRef, Copyright 2017, American Geosciences Institute.
Update Code: 1992
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