The land-based controlled-source electromagnetic (CSEM) method is an important tool in mapping subsurface resistivity contrast, especially for conductive target embedded in a resistive environment. For resistive targets on land, choosing an appropriate configuration to a specific field observation is quite confusing, due to the lack of systematic comparisons of different methods. We have conducted a comparison between the broadside and inline time-domain CSEM methods, using the short-offset transient electromagnetic (SOTEM) method and multitransient electromagnetic (MTEM) method as representatives respectively. We first compared the resolution of these methods by analyzing the relative target response and the misfit space of the designed models. We found that the inline MTEM method had advantages over the SOTEM method in resolving the thin resistive layer. We have developed a weighted joint inversion scheme to enhance the vertical resolution of the MTEM method. We then applied the methods to the investigation of a giant molybdenum deposit. The orebody, which is the real target of the exploration, does not have a conductivity contrast with its host. However, it sits on top of the granite porphyry, which is resistive compared with its surroundings, and so the granite porphyry becomes the resistive target for EM exploration. The results indicated that both methods are effective in locating large resistive target, yet the MTEM method outperforms the SOTEM method when a thick conductive overburden is presented.