We applied seismic modeling for a detailed 3D geologic model of the Flin Flon mining camp (Canada) to address some imaging and interpretation issues related to a 3D survey acquired in the camp and described in a complementary paper (part 1). A 3D geologic volumetric model of the camp was created based on a compilation of geologic data constraints from drillholes, surface geologic mapping, interpretation of 2D seismic profiles, and 3D surface and grid geostatistical modeling techniques. The 3D modeling methodology was based on a hierarchical approach to account for the heterogeneous spatial distribution of geologic constraints. Elastic parameters were assigned within the model based on core sample measurements and correlation with the different lithologies. The phase-screen algorithm used for seismic modeling was validated against analytic and finite-difference solutions to ensure that it provided accurate amplitude-variation-with-offset behavior for dipping strata. Synthetic data were generated to form zero-offset (stack) volume and also a complete prestack data set using the geometry of the real 3D survey. We found that the ability to detect a clear signature of the volcanogenic massive sulfide with ore deposits is dependent on the mineralization type (pyrite versus pyrrhotite rich ore), especially when ore-host rock interaction is considered. In the presence of an increasing fraction of the host rhyolite rock within the model volume, the response from the lower impedance pyrrhotite ore is masked by that of the rhyolite. Migration tests showed that poststack migration effectively enhances noisy 3D DMO data and provides comparable results to more computationally expensive prestack time migration. Amplitude anomalies identified in the original 3D data, which were not predicted by our modeling, could represent potential exploration targets in an undeveloped part of the camp, assuming that our a priori earth model is sufficiently accurate.