A target-oriented algorithm is developed for the prediction of multiples recorded on ocean-bottom cables by utilizing apparent slowness relations in common-source and common-receiver gathers. It is based on combining offsets and times of direct waves and primary reflections to predict multiples by matching apparent slownesses at all source and receiver locations; all higher-order multiples can be predicted by matching apparent slownesses alternately in common-source and common-receiver gathers. No knowledge of the subsurface velocity is required. Traveltimes of the direct waves and primary reflections need to be picked from common-source gathers. The subtraction of multiples involves flattening the predicted times of the multiple events, subtracting a local spatial average trace from each trace, within a fixed time window containing the wavelet of the multiple, and then shifting the data back to its original times. Tests of synthetic and field data indicate that the proposed method predicts multiples very well and removes them from seismic data efficiently with negligible affect on the primary reflections, as long as the primary and multiple reflections do not overlap in time and slowness over substantial windows in the domain in which the removal is done.