Recently, the effectiveness of the use of traditional methods of searching for kimberlite pipes in the Arkhangelsk diamondiferous province (subarctic zone of Russia) has decreased greatly. Thus, new methods of kimberlite exploration need to be developed. This study discusses new patterns of the distribution of natural radioactive isotopes within the Arkhangelsk diamondiferous province (Zolotitskoe kimberlite field), in particular the isotopes of uranium 234U and 238U. A variety of isotopic radiogeochemical studies has shown that the kimberlite pipes are characterized by local radioisotope anomalies, on the surface and in exploration drill core. These irregularities are clearly manifested in the formation of non-equilibrium anomalous isotopic composition of uranium in the surrounding rocks and groundwater of the near-contact zone of the pipes. These uranium isotopes can be used to explore for kimberlites in other areas with similar complex landscape-geological and climate conditions of the subarctic zone.