The St. Cyr klippe, part of the Yukon–Tanana terrane in Yukon, Canada, preserves fresh and retrogressed eclogite hosted by quartzofeldspathic schists. Petrology, mineral chemistry and compositional zoning combined with isochemical phase equilibrium (pseudosection) modeling shows that eclogites followed a clockwise pressure–temperature path. An amphibolite facies, pre-eclogite stage (pre-Stage I) preceded early eclogite-facies conditions of about 16 kbar and 510 °C (Stage I) and the peak pressure (Stage II), which reached up to 20 kbar and 670 °C. The peak observed and modeled eclogite-facies assemblage is garnet, omphacite, Na-rich amphibole, phengite, quartz and rutile. Pseudosections were modeled for varying Fe3+ contents, and Fe3+ = 20 % of total Fe is found to best match the pyrope and grossular content observed in garnet. Retrogression back to amphibolite-facies conditions (Stage III) followed a clockwise path as temperature decreased during decompression without passing through the chlorite stability field. U-Pb SIMS (secondary ion mass spectrometry) dating and trace-element analysis of zircon shows that the protolith of the eclogites formed within the Yukon–Tanana terrane during early arc activity, between 364 and 380 Ma. The rocks were then subducted to mantle depths and metamorphosed to eclogite-facies conditions during the Late Permian, between 267 and 271 Ma. These medium-temperature eclogites are part of a coherent high-pressure (HP) terrane that was tectonically eroded from the Yukon-Tanana composite arc in a subduction zone environment.