The interaction between phenyl salicylate and sepiolite has been studied using drug-clay systems obtained by melting and grinding. The samples have been characterized by powder X-ray diffraction, differential thermal and thermogravimetric analyses, and Vis-UV and FT-IR spectroscopies. "Free" water molecules are steadily substituted by the drug molecules, without any chemical change as shown by FT-IR. The systems prepared improved the protecting ability of the pure sepiolite or the pure drug against ultraviolet radiation, especially in the so-called "C" range (290-190 nm).

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