An integrated aeromagnetic-geologic interpretation of the Moak Lake – Setting Lake structure, a distinctive magnetic feature which contains the Manitoba nickel belt, is presented. This structure is separated, on the basis of aeromagnetic and geologic data, into eastern and western areas. A main fault zone, which is mapped in part and is also an aeromagnetic lineament, separates the two areas. It is deduced that the western area of the Moak Lake – Setting Lake structure was involved in the Hudsonian orogeny only. The eastern area is interpreted to have been initially involved in the Kenoran (?) orogeny, which produced the characteristic charnockite and pyroxene granulite rocks, and was then reinvolved in the dynamic effects of the Hudsonian orogeny. A chronologic sequence of the major events in the area is presented.