African landscape evolution since 66 Ma reflects interactions among parts of the Earth system from the Core to the Biosphere. We stress changes in those interactions in three events that have dominated landscape development: (i) a climatic revolution when the circumpolar current and the East Antarctic ice sheet first formed ∼37 Ma; (ii) a tectonic revolution at ∼32 Ma dominated by elevation of ∼30 topographic structural swells continent-wide; and (iii) a second climatic revolution in a Northern Hemisphere cooling event (at ∼2.7 Ma) that triggered Sahara desert initiation and the beginning of glacial cycles in the Northern Hemisphere (∼2.15 Ma). We recognize the following distinct features of the great Afro-Arabian continent (∼40 M km2) that show its relationship to Earth structure and processes: deep mantle structure and dynamics, plate motion with respect to that structure, especially plate-arrest (∼32 Ma). The topographic, erosional, geomorphic, and depositional modifications following that tectonic event were strongly influenced by changes around the continent in oceanic and atmospheric circulation that affected the entire continent. Atmospheric circulation changes since ∼34 Ma have involved zonal winds, the ITCZ, desert formation and destruction, the evolution of the persistent (since ∼35 Ma) Antarctic ice sheet, and since ∼2 Ma of the rapidly cycling Eurasian ice sheets. We explain that a widely supported idea that ancient erosion surfaces have survived at high elevations in Africa is the result of a failure to recognize that the present elevations of the continent’s swells are dynamically maintained, but do not display a thermochronological signature because they are young (less than ∼32 My), so that conduction of heat from shallow convection cells has not yet reached the Earth’s surface.