Salt dissolution collapse-subsidence is proposed as the dominant tectono-stratigraphic control on the deposition of major sand trends across the northern Athabasca Oil Sands Deposit. Salt removal along linear dissolution trends 200 m below in the Prairie Evaporite (Middle Devonian) halite beds resulted in the collapse of the overlying Upper Devonian strata. The collapse-induced differential subsidence of the fault blocks formed the floor underlying the McMurray deposits in the 50 km long V-shaped Bitumount Trough extending across the northern area of the Athabasca Oil Sands Deposit. The lower and middle-upper McMurray sand trends filled the accommodation created by collapses of a linear chain of Upper Devonian fault blocks along the northern margin of the western Trough. A pair of tens-of-metres thick and 20–30 km long sand trends developed parallel in overlying accumulations of the lower and middle-upper McMurray Formation (Aptian). This half-graben tilted northward as the dissolution trend in the underlying Prairie Evaporite salt scarp widened, and the scarp margin was deeply embayed. Salt dissolution-induced structures were the principal control that located the large sand complexes exploited by bitumen mining projects. Earlier models of McMurray architecture interpreted the underlying karst collapse to have been largely pre-Cretaceous. This new architectural model reinterprets the spatio-temporal balance between erosion at the pre-Cretaceous surface and within the buried salt beds. Extensive salt removal resulted in collapse of the underlying hypogene karst during the late Aptian age. This resulted in the over-thickened multi-kilometres long McMurray sand trends. The underlying karst collapse resulted in unstable deposition surfaces along the sub-Cretaceous trough floors. This tectono-stratigraphic architecture, called the syndepositional model in this study, is proposed as an alternative to two other models, one of which proposes that deeply incised channel valleys and fills resulted from multiple significant sea-level fluctuations, while the other proposes that stacked parasequences accumulated along overlying shallow channels that meandered across a stable fluvio-estuarine coast.