The south-central Intermontane belt of British Columbia has a complex architecture comprising late Paleozoic to Mesozoic volcanic and plutonic arc magmatic suites, marine and nonmarine clastic basins, high-grade metamorphic complexes, and accretionary rocks. Jurassic and Cretaceous clastic basins within this framework contain stratigraphy with hydrocarbon potential. The geology is complicated by Cretaceous to Eocene deformation, dismemberment, and dislocation. The Eocene to Neogene history of the southern Intermontane belt is dominated by non-arc volcanism, followed by Pleistocene to Recent glaciation. The volcanic and glacial cover makes this a difficult region to explore for resources. Much recent work has involved re-evaluating the challenges that the overlying volcanic cover has historically presented to geophysical imaging of the sedimentary rocks in this region in light of technological advances in geophysical data collection and analysis. This paper summarizes the lithological and stratigraphic framework of the region, with emphasis on description of the sedimentary units that have been the targets of hydrocarbon exploration.