The Boothia mainland region of the north-central Rae domain is underlain by remnants of a Neoarchean volcano sedimentary sequence dismembered by two regionally extensive Neoarchean high-potassium granitoid suites with rare occurrences of a structurally interleaved, Paleoproterozoic sedimentary cover sequence. The granitoids and their gneissic equivalents are dominated by variably deformed and metamorphosed I-type, metaluminous, polyphase, commonly porphyritic to augen, biotite ± hornblende monzogranite, and subordinate granodiorite, with rare tonalite. New geochronological results, the first for this area, demonstrate that the widespread Neoarchean granitoid plutonism is dominantly 2.61–2.59 Ga, with a less prominent 2.66 Ga plutonic event. The age of zircon recrystallization suggests that ca. 2.60 Ga Archean metamorphism and fabric development (S1) affected the 2.66 Ga plutons prior to or contemporaneously with intrusion of the voluminous ca. 2.6 Ga suite. εNd(t) for the ca. 2.61–2.59 Ga suite range from 1.4 to –1.9, overlapping with the ca. 2.66 Ga suite that range from 1.4 to 1.5. The Nd isotopic data, coupled with the presence of inherited ca. 2.65, 2.70, and 2.85–2.90 Ga zircon, suggests recycling of older, Neoarchean to Mesoarchean crust in the formation of these suites. Metaplutonic rocks preserve Paleoproterozoic deformation (F4 and F5) and amphibolite-facies metamorphism, sporadically recorded in zircon rims that formed at 1.81 Ga. This event strongly reoriented the Neoarchean fabrics in metaplutonic rocks, generally without the development of a new coaxial Paleoproterozoic fabric, and we attribute this strain and metamorphism to the Hudsonian orogeny.