The sedimentary record in a 40.9 m giant (Calypso) piston core (MD02-2494) raised from the inner basin within Effingham Inlet, British Columbia, Canada, during the 2002 Marges Ouest Nord Américaines (MONA) campaign, spans from 14 360 14C years BP (17 300 calibrated calendar (cal.) years BP) to about nine centuries before present. The core archives changes in sedimentation and sea level immediately following deglaciation of the Late Wisconsin Fraser Glaciation, which peaked about 15 000 14C years BP. The presence of the Mazama Ash in the core anchors a detailed chronology based on 49 radiocarbon dates and seven Pleistocene paleomagnetic secular variation correlations. Diatom assemblages identify a marine–freshwater–marine transition in the basin, which occurred 11 630 14C years BP (13 500 cal. years BP). At this time, a bedrock sill, presently at 46 m depth, was briefly exposed as sea level fell and then rose again during isostatic crustal adjustments. These data constrain a new sea-level curve for the outer coast of Vancouver Island covering the past 12 000 14C years BP (14 000 cal. years BP), providing new information on the nature of deglaciation along the west coast of Canada and informing interpretations of regional paleoceanographic records and mantle viscosity models.