Magnetotelluric (MT) measurements to image the three-dimensional resistivity structure of the North American continent from an Archean core to a region of Tertiary assembly were recorded at almost 300 sites along 3200 km of profiles on the LithoprobeSlave – Northern Cordillera Lithospheric Evolution (SNORCLE) transect in northwestern Canada. At the largest scale, the MT results indicate significant lithospheric thickness variation, from 260 km at the southwest margin of the Slave craton to significantly < 100 km at the southwestern end of the SNORCLE transect in the Cordillera. At intermediate scale, the resistivity results allow broad terrane subdivisions to be made. Several anomalously conductive zones along the SNORCLE transect, in rocks ranging in age from Archean to Tertiary, are attributed to the introduction of either water or carbon into the crust and mantle during subduction processes. At the local scale, the MT data image two major faults crossing the study area, the Great Slave Lake shear zone and the Tintina Fault. The resistivity images show that both the Tintina Fault and Great Slave Lake shear zone form crustal-scale features, and that the Tintina Fault has a remarkably uniform resistivity signature over a 400 km strike length in the study area. Arguably the most controversial conclusion reached is that the MT data do not support the western extension of North American autochthonous basement suggested from interpretation of the seismic reflection data.