This study reports new sensitive high-resolution ion microprobe (SHRIMP) and thermal ionization mass spectrometry (TIMS) U–Pb geochronological data for thirteen rocks from the Archean to Paleoproterozic Sask Craton, the Peter Lake Domain and Hearne margin, Saskatchewan. Seven samples from the exposed Sask Craton in both the Glennie Domain and Pelican Window record zircon growth between 2425 and 2525 Ma and at ∼1800 Ma. Older precursor material has been identified, most notably a refined crystallization age of 3117 Ma for a sample of quartzofeldspatic gneiss (“Q-gneiss”) in the Pelican Window, which also experienced ca. 2450 Ma zircon growth. Three samples from the Peter Lake Domain and a sample from the Linn Island inlier of the Wollaston Domain yield ages of ∼2575 Ma. One sample from the Peter Lake Domain is distinctly older, yielding an age of 2640 Ma, but also displays zircon growth at 2575 Ma. The simplest interpretation of these data is that the Peter Lake Domain is likely a part of the Hearne margin, although the significance and distribution of 2575 Ma ages within the larger Hearne craton is unclear. Conversely, the age range of most samples from the Sask Craton is distinctly younger than those of the Peter Lake and Hearne margin rocks. We suggest that 2.45 Ga was a major episode of magmatic reworking of older material within the Sask Craton, which includes, but is not restricted to, 3.1 Ga precursors. These ages do not coincide with typical ages reported from the Superior craton and thus the data, although limited, support an exotic origin for the Sask Craton.