We present 40Ar/39Ar hornblende and muscovite data from a 200 km transect across the northern flank of the Paleoproterozoic Trans-Hudson Orogen (THO) exposed along Reindeer Lake in Saskatchewan, Canada. The transect crosses a series of distinct lithotectonic domains that experienced pressure–temperature (P–T) conditions of 600–730°C at 4.5–6.0 kbar (1 kbar = 100 MPa) during D2 peak metamorphism at 1820–1790 Ma. The distribution of 40Ar/39Ar hornblende ages shows that most of the transect cooled through approximately 500°C by ca. 1765 Ma, with two significant exceptions. At the north end of the transect, older ages in the Peter Lake Domain (up to 2200 Ma) suggest that this region did not experience high-grade metamorphism that affected the rest of the transect and may indicate a structural break between these Archean rocks and the Cree Lake Zone to the north. In the south-central part of the transect, U–Pb (monazite, titanite) and 40Ar/39Ar (hornblende, muscovite) ages indicate that rocks in the vicinity of the Duck Lake Shear Zone, a ductile thrust zone separating the Kisseynew and La Ronge domains, cooled at a rate of 6°C/Ma and that cooling was delayed by ca. 20–25 million years relative to that of adjacent regions. Based on generic thermal–tectonic models for large hot orogens, we suggest that delayed cooling in the vicinity of the shear zone reflects post-orogenic thermal relaxation of lower crustal isotherms that were perturbed by the effects of convergence.