The Cariboo Mountains, British Columbia, contain an intracontinental dextral strike-slip fault system that crosscuts the regional fold structures. This fault system accounts for a minimum of 120 km and a maximum of 200 km of dextral strike-slip displacement. This probably accommodates some of the motion associated with the southern termination of the Northern Rocky Mountain Trench Fault and is part of a step-over zone between the Northern Rocky Mountain Trench Fault and the Fraser River – Straight Creek fault systems. The Isaac Lake Synclinorium is a kilometre-scale Jurassic fold structure that is bounded by the dextral oblique Isaac Lake and Winder strike-slip faults. These faults are part of the regional strike-slip fault system that is found throughout the Cariboo Mountains. Deformation associated with the strike-slip faults is complex and is partitioned into motion along the faults and into the formation of kilometre-scale folds that are found in areas between the faults. The angular relationship between the strike-slip faults and folds conforms to models developed for dextral strike-slip fault systems with drag on high-friction faults. We interpreted these structures to have formed during a continuous deformation event. Timing constraints indicate that faulting started by the Late Cretaceous and may have had a long and protracted history into the Tertiary.