New U–Pb zircon, titanite, and monazite ages reported here, along with existing age data, demonstrate that granitoid bodies in the northwestern segment of the Paleoproterozoic Makkovik Province, Labrador, are of three distinct ages. The redefined Island Harbour Bay plutonic suite consists of varied dioritic to granitic units that were syntectonically emplaced into Archean crust of the Kaipokok domain between ca. 1895 Ma and 1870 ± 2 Ma. This plutonism occurred during the early stages of the Makkovikian Orogeny in an obliquely convergent, Andean continental margin setting. The Hares Islands and Drunken Harbour granites form smaller, discrete plutons that were emplaced in or adjacent to the Island Harbour Bay plutonic suite at 1805 ± 5 Ma and 1791 ± 2 Ma, respectively, during dextral strike-slip deformation that accompanied accretion of an outboard juvenile terrane. Magmatic activity during this period was preferentially sited along active structural zones, but also occurred outside of these zones. The undeformed Blacklers Bight A-type granite was emplaced in the Kaipokok domain at 1716 ± 1 Ma, late in the development of the orogen. A-type granites of this age form a significant component of the southeastern Makkovik Province, and their generation is linked to mafic underplating and heterogeneous regional extension. The new age data support the conclusion of earlier workers that crustal growth via synorogenic and postorogenic plutonism was episodic, and allow, along with field and geochemical data, inferences to be made regarding the tectonic setting of individual plutonic events.