The Anialik River area in the northwestern Slave Province comprises two geological domains of different age and origin that were tectonically juxtaposed at ca. 2650 Ma. The older domain, the Kangguyak gneiss belt, comprises ca. 3300-2700 Ma orthogneisses and paragneisses, interpreted as the remnants of a Mesoarchean continental margin. The younger domain, the Anialik River greenstone belt, consists of ca. 2680 Ma mafic to felsic volcanic rocks interpreted to have formed in an ensimatic island-arc setting. Structural and geochronological evidence suggest collision of the two domains began around 2650 Ma in a transpressive regime that involved oblique (sinistral) subduction of the greenstone belt beneath the Kangguyak domain along the Tokhokatak shear zone. Displacement continued until at least ca. 2600 Ma, when late, two-mica granites intruded along and were deformed in the shear zone. Following ca. 2600 Ma, rocks in both domains and along the fault cooled rapidly to about 350°C. Strongly overprinted muscovite spectra and the young ages for biotite throughout the region imply that a thermal event reset all biotites (but not muscovite) at ca. 2000-1900 Ma, possibly associated with crustal thickening associated with Wopmay (Calderian) orogenesis. The tectonic history of the Anialik River area is significantly different from that documented in the south-central part of the Slave Province, suggesting the Kangguyak domain is a distinct fragment of continental crust that accreted independently from continental crust in the southern Slave Province.