Lithological and structural mapping in the east Wekusko Lake area of the Flin Flon Belt, Trans-Hudson Orogen, suggested an intimate relationship between magmatism, fluvial sedimentation, and initiation of fold and thrust belt deformation. Conventional U-Pb geochronology of volcanic rocks in fault-bounded assemblages provides a minimum age of 1876 ± 2 Ma for McCafferty Liftover back-arc basalts, and ages of between 1833 and 1836 Ma for the Herb Lake volcanic rocks. A rhyolite which unconformably overlies Western Missi Group fluvial sedimentary rocks has complex zircon systematics. This rock may be as old as about 1856 Ma or as young as 1830 Ma. The sedimentary rocks overlying this rhyolite are locally intercalated with 1834 Ma felsic volcanic rocks, and yield sensitive high resolution ion microprobe (SHRIMP) U-Pb and Pb-evaporation detrital zircon ages ranging from 1834 to 2004 Ma. The Eastern Missi Group is cut by an 1826 ± 4 Ma felsic dyke, and contains 1832-1911 Ma detrital zircons. The dominant source for detritus in the Missi Group was the Flin Flon accretionary collage and associated successor arc rocks. The fluvial sedimentary rocks and the Herb Lake volcanic rocks were essentially coeval, and were then incorporated into a southwest-directed fold and thrust belt which was initiated at about 1840 Ma and active until at least peak regional metamorphism.