This paper describes the geology, geochemistry, and age of two amphibolite facies volcano-plutonic assemblages in the southern Hanson Lake Block and southeastern Glennie Domain of the Paleoproterozoic Trans-Hudson Orogen of east-central Saskatchewan. The Hanson Lake assemblage comprises a mixed suite of subaqueous to subaerial dacitic to rhyolitic (ca. 1875 Ma) and intercalated minor mafic volcanic rocks, overlain by greywackes. Similarly with modern oceanic island arcs, the Hanson Lake assemblage shows evolution from primitive arc tholeiites to evolved calc-alkaline arc rocks. It is intruded by younger subvolcanic alkaline porphyries (ca. 1861 Ma), synvolcanic granitic plutons (ca. 1873 Ma), and the younger Hanson Lake Pluton (ca. 1844 Ma). Rocks of the Northern Lights assemblage are stratigraphically equivalent to the lower portion of the Hanson Lake assemblage and comprise tholeiitic arc pillowed mafic flows and felsic to intermediate volcaniclastic rocks and greywackes, which can be traced as far west as Wapawekka Lake in the south-central part of the Glennie Domain. The Hanson Lake volcanic belt, comprising the Northern Lights and Hanson Lake assemblages, shows strong lithological, geochemical, and geochronological similarities to lithotectonic assemblages of the Flin Flon Domain (Amisk Collage), suggesting that all of these areas may have been part of a more or less continuous island arc complex, extending from Snow Lake to Flin Flon, across the Sturgeon-Weir shear zone into the Hanson Lake Block and across the Tabbernor fault zone into the Glennie Domain.