The Kisseynew Domain is a metasedimentary belt in the central Reindeer Zone of the Trans-Hudson Orogen. It is bounded by 1.92–1.86 Ga volcanic–plutonic belts to the north and south, by an Archean terrane to the east (Superior Province), and by a volcanic-plutonic terrane underlain by an Archean terrane to the southwest (Glennie Domain). The Kisseynew Domain developed in an arc-related setting in the final stages of plate convergence involving the northward migration of arc–ocean floor complexes toward the Archean Hearne Craton. Terminal collision, involving also the Superior Craton, originated multiple fold–thrust systems and high-grade metamorphism. U–Pb ages of 1874–1860 Ma for pretectonic plutonic units in southern Kisseynew Domain are identical to ages of plutonism intruding the arc–ocean floor accretionary complex in the Flin Flon domain (Amisk collage) and indicate its northern extension. Deposition of the Burntwood Group turbidites started at ca. 1860 Ma, indicating uplift and erosion of the volcanic complexes and was coeval with arc magmatism that succeeded the Amisk collage. From 1848 Ma, Burntwood sedimentation was coeval with deposition of Missi Group continental sediments, with continental arc magmatism and early deformation. New and published ages for detrital zircon indicate that sediments were derived both from local 1.89–1.84 Ga units and also from 2.55–2.36 Ga sources. The latter suggest that a Neoarchean–Paleoproterozoic cratonic block was undergoing erosion, remnants of which occur in the Flin Flon Belt. Basin closure started after 1823 Ma and is marked by regional high-grade metamorphism lasting for ca. 30 million years from 1818 Ma to 1785 Ma; late- to posttectonic metamorphic activity lasted until ca. 1775 Ma.