Geochemistry and Nd isotopic compositions are used to characterize mantle and crustal sources and to provide constraints on petrogenetic models for tholeiitic, calc-alkalic, and lamprophyric suites in the Kamiskotia–Montcalm area. The Kamiskotia gabbroic complex (KGC) and cogenetic, bimodal volcanic rocks have εNd(t) = +2.2 to +2.6, consistent with a direct derivation from a long-term, light rare-earth element (LREE)-depleted mantle. The Montcalm gabbroic complex has decreasing εNd(t) upsection from +2.8 to +1.0, consistent with contamination by long-term, LREE-enriched (with respect to the long-term, LREE-depleted Abitibi mantle) crust during fractionation. Two calc-alkalic lamprophyre samples, characterized by large-ion lithophile element (LILE) and LREE enrichment and high MgO, Ni, and Cr contents, have εNd(t) of +2.5 and +2.8, indicating a derivation from a depleted mantle source that had undergone recent trace-element enrichment. A different lamprophyre suite is extremely LILE and LREE enriched and has an εNd(t) of +1.0, indicating a derivation from a slightly different source that had earlier LREE enrichment. Granitoid rocks internal and external to greenstone belt rocks have εNd(t) = +2.5 to +3.8 and +0.6 to −0.4, respectively. The lower values provide additional evidence for the existence of LREE-enriched crust in this area.Considering these data along with other radiogenic isotope studies, a petrogenetic and tectonic model is suggested for the crustal development of the southern Abitibi Subprovince. From >2740 to 2698 Ma—the major period of volcanic activity—komatiitic and tholeiitic suites and one lamprophyre suite were derived from a uniformly LREE-depleted mantle reservoir with εNd(t) = +2 to +3. Calc-alkalic granitoids were emplaced generally after 2700 Ma. Their long-term, LREE-depleted and LREE-enriched Nd isotopic signatures are similar to signatures in continental-arc settings (e.g., the Coastal Batholith of Peru). Form 2690 to 2670 Ma, when transpressional tectonism prevailed, mantle-derived magmatism was represented by long-term, LREE-enriched (εNd(t) = +1 to +2) lamprophyric and alkalic volcanic suites.The Kamiskotia suite has a seven-point, whole-rock – mineral isochron Sm–Nd age of 2710 ± 30 Ma, identical to U–Pb zircon ages for the suite, indicating closed-system behavior. An Rb–Sr mineral – whole-rock isochron age from one KGC sample is 2450 ± 30 Ma, identical to U–Pb ages for the Hearst–Matachewan dike swarm, a prominent feature in the KGC area. Regression of whole-rock and mineral-isotope data for one granitoid sample with a U–Pb zircon age of 2696 ± 1.5 Ma gives identical ages of 2530 ± 30 Ma in the Sm–Nd and Rb–Sr systems. The latter data add to an increasing body of evidence for cryptic, late thermal events after granitoid–greenstone belt development in the southern Abitibi Subprovince.